Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells.

Liu, Wei

Vitamin D and its analog EB1089 induce p27 accumulation and diminish association of p27 with Skp2 independent of PTEN in pituitary corticotroph cells. [electronic resource] - Brain pathology (Zurich, Switzerland) Oct 2002 - 412-9 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

1015-6305

10.1111/j.1750-3639.2002.tb00458.x doi


Adenoma--drug therapy
Adrenocorticotropic Hormone--metabolism
Animals
CDC2-CDC28 Kinases
Calcitriol--analogs & derivatives
Cell Cycle--drug effects
Cell Cycle Proteins--agonists
Cells, Cultured
Cyclin-Dependent Kinase 2
Cyclin-Dependent Kinase Inhibitor p27
Cyclin-Dependent Kinases--antagonists & inhibitors
Cysteine Endopeptidases--drug effects
Humans
Multienzyme Complexes--drug effects
PTEN Phosphohydrolase
Phosphoric Monoester Hydrolases--metabolism
Pituitary Neoplasms--drug therapy
Proteasome Endopeptidase Complex
Protein Serine-Threonine Kinases--antagonists & inhibitors
S-Phase Kinase-Associated Proteins
Tumor Suppressor Proteins--agonists
Up-Regulation--drug effects
Vitamin D--analogs & derivatives