Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.
Bharti, Alok C
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. [electronic resource] - Blood Feb 2003 - 1053-62 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0006-4971
10.1182/blood-2002-05-1320 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Division--drug effects
Curcumin--pharmacology
Down-Regulation--drug effects
Drug Synergism
G1 Phase--drug effects
Humans
I-kappa B Kinase
Multiple Myeloma--drug therapy
NF-kappa B--antagonists & inhibitors
Phosphorylation--drug effects
Protein Serine-Threonine Kinases--antagonists & inhibitors
Tumor Cells, Cultured
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis. [electronic resource] - Blood Feb 2003 - 1053-62 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0006-4971
10.1182/blood-2002-05-1320 doi
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Cell Division--drug effects
Curcumin--pharmacology
Down-Regulation--drug effects
Drug Synergism
G1 Phase--drug effects
Humans
I-kappa B Kinase
Multiple Myeloma--drug therapy
NF-kappa B--antagonists & inhibitors
Phosphorylation--drug effects
Protein Serine-Threonine Kinases--antagonists & inhibitors
Tumor Cells, Cultured