Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation.
Ulloa, Luis
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Sep 2002 - 12351-6 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
0027-8424
10.1073/pnas.192222999 doi
Animals
Cell Line
Endotoxemia--complications
Enzyme Activation--drug effects
HMGB1 Protein--metabolism
Lipopolysaccharides--toxicity
Macrophages--drug effects
Male
Mice
Mice, Inbred BALB C
Mitogen-Activated Protein Kinases--metabolism
NF-kappa B--genetics
Pyruvates--administration & dosage
RNA, Messenger--genetics
Sepsis--complications
Signal Transduction--drug effects
Systemic Inflammatory Response Syndrome--drug therapy
Tumor Necrosis Factor-alpha--genetics
p38 Mitogen-Activated Protein Kinases
Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. [electronic resource] - Proceedings of the National Academy of Sciences of the United States of America Sep 2002 - 12351-6 p. digital
Publication Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.
0027-8424
10.1073/pnas.192222999 doi
Animals
Cell Line
Endotoxemia--complications
Enzyme Activation--drug effects
HMGB1 Protein--metabolism
Lipopolysaccharides--toxicity
Macrophages--drug effects
Male
Mice
Mice, Inbred BALB C
Mitogen-Activated Protein Kinases--metabolism
NF-kappa B--genetics
Pyruvates--administration & dosage
RNA, Messenger--genetics
Sepsis--complications
Signal Transduction--drug effects
Systemic Inflammatory Response Syndrome--drug therapy
Tumor Necrosis Factor-alpha--genetics
p38 Mitogen-Activated Protein Kinases