Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER.

Yang, Tong

Crucial step in cholesterol homeostasis: sterols promote binding of SCAP to INSIG-1, a membrane protein that facilitates retention of SREBPs in ER. [electronic resource] - Cell Aug 2002 - 489-500 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0092-8674

10.1016/s0092-8674(02)00872-3 doi


CCAAT-Enhancer-Binding Proteins--metabolism
Cell Membrane--metabolism
Cells, Cultured
Cholesterol--biosynthesis
DNA-Binding Proteins--metabolism
Endoplasmic Reticulum--metabolism
Eukaryotic Cells--cytology
Gene Expression Regulation--physiology
Genetic Vectors--physiology
Golgi Apparatus--metabolism
Homeostasis--genetics
Humans
Intracellular Signaling Peptides and Proteins
Membrane Proteins--genetics
Mutation--genetics
Peptide Hydrolases--metabolism
Protein Binding--physiology
Protein Structure, Tertiary--physiology
Protein Transport--physiology
Proteins--genetics
Sterol Regulatory Element Binding Protein 1
Sterols--metabolism
Transcription Factors
Transfection