Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1.

Hagting, Anja

Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. [electronic resource] - The Journal of cell biology Jun 2002 - 1125-37 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9525

10.1083/jcb.200111001 doi


Anaphase--physiology
Biomarkers
Cell Cycle Proteins--genetics
Cell Line
Chromatids--physiology
Cyclin B--metabolism
Cyclin B1
Cyclin-Dependent Kinases--metabolism
HeLa Cells
Humans
Hydrolysis
Kinetics
Metaphase--physiology
Mutation
Neoplasm Proteins--metabolism
Phenotype
Recombinant Fusion Proteins--metabolism
Securin
Sequence Deletion
Spindle Apparatus--physiology
Transcriptional Activation
Tumor Cells, Cultured
Ubiquitins--metabolism