Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment.

Joseph, Bertrand

Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment. [electronic resource] - Oncogene Jan 2002 - 65-77 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0950-9232

10.1038/sj.onc.1205018 doi


Amino Acid Chloromethyl Ketones--pharmacology
Apoptosis--drug effects
Apoptosis Inducing Factor
Carcinoma, Non-Small-Cell Lung--pathology
Carcinoma, Small Cell--pathology
Caspase 3
Caspase 7
Caspases--biosynthesis
Cell Cycle--drug effects
Cell Nucleus--drug effects
Cysteine Proteinase Inhibitors--pharmacology
Cytochrome c Group--analysis
Drug Resistance, Neoplasm
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Enzyme Precursors--biosynthesis
Flavoproteins--physiology
Gamma Rays
Humans
Jurkat Cells--drug effects
Lung Neoplasms--pathology
Membrane Potentials--drug effects
Membrane Proteins--physiology
Mitochondria--physiology
Poly(ADP-ribose) Polymerases--metabolism
Protein Transport
Radiation Tolerance
Reactive Oxygen Species--metabolism
Recombinant Fusion Proteins--physiology
Staurosporine--pharmacology
Superoxides--metabolism
Tumor Cells, Cultured--drug effects