Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase.

Brann, Adi B

Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase. [electronic resource] - The Journal of biological chemistry Mar 2002 - 9812-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0021-9258

10.1074/jbc.M109862200 doi


Age Factors
Amides--metabolism
Animals
Axons--metabolism
Blotting, Western
Cell Death
Cells, Cultured
Ceramides--metabolism
Dose-Response Relationship, Drug
Hippocampus--cytology
Mice
Mice, Inbred C57BL
Mitogen-Activated Protein Kinase 8
Mitogen-Activated Protein Kinases--metabolism
Nerve Growth Factor--metabolism
Neurons--metabolism
Phosphorylation
Pyrones--metabolism
Rats
Rats, Wistar
Receptor, Nerve Growth Factor
Receptors, Nerve Growth Factor--metabolism
Reverse Transcriptase Polymerase Chain Reaction
Signal Transduction
Sphingomyelin Phosphodiesterase--metabolism
Time Factors