Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases.

Solorzano, C C

Inhibition of growth and metastasis of human pancreatic cancer growing in nude mice by PTK 787/ZK222584, an inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. [electronic resource] - Cancer biotherapy & radiopharmaceuticals Oct 2001 - 359-70 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.

1084-9785

10.1089/108497801753354267 doi


Adenocarcinoma--blood supply
Angiogenesis Inhibitors--administration & dosage
Animals
Antineoplastic Combined Chemotherapy Protocols--therapeutic use
Apoptosis--drug effects
Deoxycytidine--administration & dosage
Enzyme Inhibitors--administration & dosage
Humans
In Situ Nick-End Labeling
Male
Mice
Mice, Nude
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasm Proteins--analysis
Neoplasm Transplantation
Pancreatic Neoplasms--blood supply
Phthalazines--administration & dosage
Platelet Endothelial Cell Adhesion Molecule-1--analysis
Proliferating Cell Nuclear Antigen--analysis
Pyridines
Receptor Protein-Tyrosine Kinases--antagonists & inhibitors
Receptors, Growth Factor--antagonists & inhibitors
Receptors, Vascular Endothelial Growth Factor
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Gemcitabine