The cyclin-dependent kinase inhibitor roscovitine inhibits the transactivating activity and alters the posttranslational modification of herpes simplex virus type 1 ICP0.

Davido, David J

The cyclin-dependent kinase inhibitor roscovitine inhibits the transactivating activity and alters the posttranslational modification of herpes simplex virus type 1 ICP0. [electronic resource] - Journal of virology Feb 2002 - 1077-88 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-538X

10.1128/jvi.76.3.1077-1088.2002 doi


Animals
Cell Nucleus--metabolism
Chlorocebus aethiops
Cyclin-Dependent Kinases--antagonists & inhibitors
Electrophoresis, Polyacrylamide Gel
Enzyme Inhibitors--pharmacology
Gene Expression
Genetic Engineering
Herpesvirus 1, Human--drug effects
Humans
Immediate-Early Proteins--drug effects
Peptide Mapping
Phosphoproteins--analysis
Phosphorylation--drug effects
Promoter Regions, Genetic
Protein Processing, Post-Translational--drug effects
Purines--pharmacology
Roscovitine
Trans-Activators--drug effects
Transcriptional Activation--drug effects
Trypsin
Ubiquitin-Protein Ligases
Vero Cells
Viral Proteins--genetics
beta-Galactosidase--genetics