Induction of G(2)/M phase arrest and apoptosis by a new synthetic anti-cancer agent, DW2282, in promyelocytic leukemia (HL-60) cells.

Piao, W

Induction of G(2)/M phase arrest and apoptosis by a new synthetic anti-cancer agent, DW2282, in promyelocytic leukemia (HL-60) cells. [electronic resource] - Biochemical pharmacology Dec 2001 - 1439-47 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-2952

10.1016/s0006-2952(01)00796-1 doi


Antineoplastic Agents--pharmacology
Apoptosis
CDC2 Protein Kinase--metabolism
Caspase 3
Caspases--metabolism
Cell Division--drug effects
Down-Regulation--drug effects
Enzyme Activation--drug effects
G2 Phase--drug effects
HL-60 Cells
Humans
Imidazoles--pharmacology
Leukemia, Promyelocytic, Acute
Mitosis--drug effects
Poly (ADP-Ribose) Polymerase-1
Poly(ADP-ribose) Polymerases
Proteins--metabolism
Proto-Oncogene Proteins c-bcl-2--biosynthesis
Sulfones--pharmacology