A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule.
Carducci, M A
A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Oct 2001 - 3047-55 p. digital
Publication Type: Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
1078-0432
Adult
Antineoplastic Agents--adverse effects
Chromatography, High Pressure Liquid
Disorders of Excessive Somnolence--chemically induced
Dose-Response Relationship, Drug
Fatigue--chemically induced
Female
Glutamine--analogs & derivatives
Humans
Hypokalemia--chemically induced
Infusions, Intravenous
Male
Metabolic Clearance Rate
Nausea--chemically induced
Neoplasms--drug therapy
Neutropenia--chemically induced
Patient Dropouts
Phenylacetates--blood
Phenylbutyrates--adverse effects
Prostate-Specific Antigen--blood
Prostatic Neoplasms--blood
Time Factors
Tumor Cells, Cultured
Uric Acid--blood
A Phase I clinical and pharmacological evaluation of sodium phenylbutyrate on an 120-h infusion schedule. [electronic resource] - Clinical cancer research : an official journal of the American Association for Cancer Research Oct 2001 - 3047-55 p. digital
Publication Type: Clinical Trial; Clinical Trial, Phase I; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
1078-0432
Adult
Antineoplastic Agents--adverse effects
Chromatography, High Pressure Liquid
Disorders of Excessive Somnolence--chemically induced
Dose-Response Relationship, Drug
Fatigue--chemically induced
Female
Glutamine--analogs & derivatives
Humans
Hypokalemia--chemically induced
Infusions, Intravenous
Male
Metabolic Clearance Rate
Nausea--chemically induced
Neoplasms--drug therapy
Neutropenia--chemically induced
Patient Dropouts
Phenylacetates--blood
Phenylbutyrates--adverse effects
Prostate-Specific Antigen--blood
Prostatic Neoplasms--blood
Time Factors
Tumor Cells, Cultured
Uric Acid--blood