IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy.

Wigginton, J M

IFN-gamma and Fas/FasL are required for the antitumor and antiangiogenic effects of IL-12/pulse IL-2 therapy. [electronic resource] - The Journal of clinical investigation Jul 2001 - 51-62 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9738

10.1172/JCI10128 doi


Angiogenesis Inhibitors--administration & dosage
Animals
Antineoplastic Agents--administration & dosage
Apoptosis--drug effects
CD8-Positive T-Lymphocytes--immunology
Carcinoma, Renal Cell--blood supply
Combined Modality Therapy
Drug Administration Schedule
Endothelium, Vascular--drug effects
Fas Ligand Protein
Immunologic Factors--administration & dosage
Injections, Intraperitoneal
Interferon-gamma--physiology
Interleukin-12--administration & dosage
Kidney Neoplasms--blood supply
Membrane Glycoproteins--deficiency
Mice
Mice, Inbred BALB C
Mice, Inbred C3H
Mice, Knockout
Mice, Mutant Strains
Neoplasm Metastasis
Neoplasm Transplantation
Neovascularization, Pathologic--drug therapy
Nephrectomy
Recombinant Proteins--administration & dosage
Specific Pathogen-Free Organisms
fas Receptor--physiology