pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase.

Lauricella, M

pRb suppresses camptothecin-induced apoptosis in human osteosarcoma Saos-2 cells by inhibiting c-Jun N-terminal kinase. [electronic resource] - FEBS letters Jun 2001 - 191-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0014-5793

10.1016/s0014-5793(01)02553-4 doi


Apoptosis--drug effects
Blotting, Western
Camptothecin--antagonists & inhibitors
Caspase 3
Caspases--metabolism
Cell Cycle--drug effects
Cell Size--drug effects
Cell Survival--drug effects
DNA Topoisomerases, Type I--metabolism
Dose-Response Relationship, Drug
Enzyme Activation--drug effects
Flow Cytometry
Glutathione--metabolism
Humans
Hydrogen Peroxide--metabolism
JNK Mitogen-Activated Protein Kinases
Mitogen-Activated Protein Kinases--antagonists & inhibitors
Oxidative Stress--drug effects
Phosphorylation--drug effects
Poly(ADP-ribose) Polymerases--metabolism
Proto-Oncogene Proteins c-jun--metabolism
Retinoblastoma Protein--genetics
Time Factors
Topoisomerase I Inhibitors
Transfection
Tumor Cells, Cultured