Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspase cascades and is independent of Fas/Fas ligand interaction.

Lai, J H

Western and Chinese antirheumatic drug-induced T cell apoptotic DNA damage uses different caspase cascades and is independent of Fas/Fas ligand interaction. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Jun 2001 - 6914-24 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0022-1767

10.4049/jimmunol.166.11.6914 doi


Alkaloids--toxicity
Anti-Inflammatory Agents, Non-Steroidal--toxicity
Apoptosis--drug effects
Benzylisoquinolines
Caspase 3
Caspase 8
Caspase 9
Caspase Inhibitors
Caspases--biosynthesis
Cell Death--drug effects
Cysteine Proteinase Inhibitors--pharmacology
DNA Damage--immunology
Drugs, Chinese Herbal--toxicity
Enzyme Activation--drug effects
Enzyme Induction--drug effects
Fas Ligand Protein
Humans
Hydroxychloroquine--toxicity
Immunity, Innate--drug effects
Jurkat Cells--cytology
Lymphocyte Activation--drug effects
Lymphocyte Count
Membrane Glycoproteins--biosynthesis
Methotrexate--toxicity
Signal Transduction--drug effects
T-Lymphocyte Subsets--cytology
Tripterygium
U937 Cells
fas Receptor--biosynthesis