KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser.

Yue, C

KN-93 inhibition of G protein signaling is independent of the ability of Ca2+/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser. [electronic resource] - Molecular and cellular endocrinology Apr 2001 - 149-56 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0303-7207

10.1016/s0303-7207(01)00383-5 doi


Amino Acid Substitution
Animals
Benzylamines--pharmacology
Binding Sites
Calcium-Calmodulin-Dependent Protein Kinase Type 2
Calcium-Calmodulin-Dependent Protein Kinases--pharmacology
Enzyme Inhibitors--pharmacology
Heterotrimeric GTP-Binding Proteins--antagonists & inhibitors
Isoenzymes--drug effects
Phosphatidylinositols--metabolism
Phospholipase C beta
Phosphorylation
Rats
Serine--metabolism
Signal Transduction--drug effects
Sulfonamides--pharmacology
Transfection
Tumor Cells, Cultured
Type C Phospholipases--drug effects