Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs.

Lunz, J G

Replicative senescence of biliary epithelial cells precedes bile duct loss in chronic liver allograft rejection: increased expression of p21(WAF1/Cip1) as a disease marker and the influence of immunosuppressive drugs. [electronic resource] - The American journal of pathology Apr 2001 - 1379-90 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.

0002-9440

10.1016/S0002-9440(10)64089-8 doi


Animals
Antibodies--pharmacology
Bile Ducts--pathology
Biomarkers
Cell Division--drug effects
Cellular Senescence--physiology
Chronic Disease
Cyclin-Dependent Kinase Inhibitor p21
Cyclins--metabolism
Cyclosporine--pharmacology
Epithelial Cells--pathology
Graft Rejection--drug therapy
Humans
Immunosuppressive Agents--therapeutic use
Intracellular Membranes--metabolism
Liver Transplantation
Male
Mice
RNA, Messenger--metabolism
Signal Transduction--physiology
Tacrolimus--pharmacology
Time Factors
Transforming Growth Factor beta--genetics