A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein.

Lamorte, L

A switch from p130Cas/Crk to Gab1/Crk signaling correlates with anchorage independent growth and JNK activation in cells transformed by the Met receptor oncoprotein. [electronic resource] - Oncogene Dec 2000 - 5973-81 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0950-9232

10.1038/sj.onc.1203977 doi


3T3 Cells
Actins--metabolism
Adaptor Proteins, Signal Transducing
Animals
Cell Adhesion
Cell Division
Cell Size
Cell Transformation, Neoplastic--metabolism
Crk-Associated Substrate Protein
Cytoskeletal Proteins--metabolism
Enzyme Activation
Fibronectins--metabolism
Focal Adhesion Kinase 1
Focal Adhesion Protein-Tyrosine Kinases
Focal Adhesions--metabolism
JNK Mitogen-Activated Protein Kinases
MAP Kinase Kinase 4
Mice
Mitogen-Activated Protein Kinase Kinases--metabolism
Mutation--genetics
Oncogene Proteins--genetics
Paxillin
Phosphoproteins--metabolism
Phosphorylation
Phosphotyrosine--metabolism
Protein Binding
Protein-Tyrosine Kinases--metabolism
Proteins
Proto-Oncogene Proteins--metabolism
Proto-Oncogene Proteins c-crk
Proto-Oncogene Proteins c-met--genetics
Retinoblastoma-Like Protein p130
Signal Transduction
Stress Fibers--metabolism
Wound Healing