The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism.

Wei, P

The nuclear receptor CAR mediates specific xenobiotic induction of drug metabolism. [electronic resource] - Nature Oct 2000 - 920-3 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0028-0836

10.1038/35038112 doi


Alanine Transaminase--biosynthesis
Animals
Aryl Hydrocarbon Hydroxylases
Cell Line
Cocaine--toxicity
Coxsackie and Adenovirus Receptor-Like Membrane Protein
Cytochrome P-450 Enzyme System--biosynthesis
Cytochrome P450 Family 2
Enzyme Induction
Female
Gene Expression Regulation, Enzymologic--drug effects
Gene Targeting
Humans
Liver--drug effects
Male
Mice
Pharmaceutical Preparations--metabolism
Phenobarbital--chemistry
Pyridines--pharmacology
Receptors, Virus--deficiency
Steroid Hydroxylases
Xenobiotics--chemistry
Zoxazolamine--metabolism