SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung.

Underwood, D C

SB 239063, a p38 MAPK inhibitor, reduces neutrophilia, inflammatory cytokines, MMP-9, and fibrosis in lung. [electronic resource] - American journal of physiology. Lung cellular and molecular physiology Nov 2000 - L895-902 p. digital

Publication Type: Journal Article

1040-0605

10.1152/ajplung.2000.279.5.L895 doi


Animals
Bleomycin--toxicity
Cells, Cultured
Cytokines--biosynthesis
Disease Models, Animal
Enzyme Inhibitors--pharmacology
Guinea Pigs
Humans
Hypertension, Pulmonary--chemically induced
Imidazoles--pharmacology
Inflammation--physiopathology
Interleukin 1 Receptor Antagonist Protein
Interleukin-1--blood
Interleukin-6--blood
Interleukin-8--blood
Lipopolysaccharides--toxicity
Lung--drug effects
Lung Diseases, Obstructive--physiopathology
Male
Matrix Metalloproteinase 9--metabolism
Mitogen-Activated Protein Kinases--antagonists & inhibitors
Neutrophils--drug effects
Pulmonary Alveoli--drug effects
Pulmonary Fibrosis--chemically induced
Pyrimidines--pharmacology
Rats
Rats, Inbred Lew
Sialoglycoproteins--blood
Tumor Necrosis Factor-alpha--metabolism
p38 Mitogen-Activated Protein Kinases