Expression of the alpha 5 integrin subunit gene promoter is positively regulated by the extracellular matrix component fibronectin through the transcription factor Sp1 in corneal epithelial cells in vitro.
Larouche, K
Expression of the alpha 5 integrin subunit gene promoter is positively regulated by the extracellular matrix component fibronectin through the transcription factor Sp1 in corneal epithelial cells in vitro. [electronic resource] - The Journal of biological chemistry Dec 2000 - 39182-92 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M002945200 doi
Animals
Antigens, CD--genetics
Base Sequence
Blotting, Western
Cell Line
Cell Nucleus--metabolism
Cells, Cultured
Chloramphenicol O-Acetyltransferase--metabolism
Cornea--metabolism
DNA--metabolism
Dose-Response Relationship, Drug
Drosophila
Electrophoresis, Polyacrylamide Gel
Enzyme Inhibitors--pharmacology
Epithelial Cells--metabolism
Extracellular Matrix--metabolism
Fibronectins--metabolism
Flavonoids--pharmacology
Gene Expression Regulation
HeLa Cells
Humans
Integrin alpha5
Ligands
MAP Kinase Kinase Kinase 1
Molecular Sequence Data
Mutagenesis, Site-Directed
Phosphorylation
Plasmids--metabolism
Promoter Regions, Genetic
Protein Binding
Protein Serine-Threonine Kinases--antagonists & inhibitors
Rabbits
Sequence Homology, Nucleic Acid
Signal Transduction
Sp1 Transcription Factor--metabolism
Transfection
Expression of the alpha 5 integrin subunit gene promoter is positively regulated by the extracellular matrix component fibronectin through the transcription factor Sp1 in corneal epithelial cells in vitro. [electronic resource] - The Journal of biological chemistry Dec 2000 - 39182-92 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0021-9258
10.1074/jbc.M002945200 doi
Animals
Antigens, CD--genetics
Base Sequence
Blotting, Western
Cell Line
Cell Nucleus--metabolism
Cells, Cultured
Chloramphenicol O-Acetyltransferase--metabolism
Cornea--metabolism
DNA--metabolism
Dose-Response Relationship, Drug
Drosophila
Electrophoresis, Polyacrylamide Gel
Enzyme Inhibitors--pharmacology
Epithelial Cells--metabolism
Extracellular Matrix--metabolism
Fibronectins--metabolism
Flavonoids--pharmacology
Gene Expression Regulation
HeLa Cells
Humans
Integrin alpha5
Ligands
MAP Kinase Kinase Kinase 1
Molecular Sequence Data
Mutagenesis, Site-Directed
Phosphorylation
Plasmids--metabolism
Promoter Regions, Genetic
Protein Binding
Protein Serine-Threonine Kinases--antagonists & inhibitors
Rabbits
Sequence Homology, Nucleic Acid
Signal Transduction
Sp1 Transcription Factor--metabolism
Transfection