The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release.

Gemignani, A

The HIV-1 coat protein gp120 and some of its fragments potently activate native cerebral NMDA receptors mediating neuropeptide release. [electronic resource] - The European journal of neuroscience Aug 2000 - 2839-46 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0953-816X

10.1046/j.1460-9568.2000.00172.x doi


2-Amino-5-phosphonovalerate--pharmacology
Animals
Cerebral Cortex--cytology
Cholecystokinin--metabolism
Dizocilpine Maleate--pharmacology
Enzyme Inhibitors--pharmacology
Excitatory Amino Acid Antagonists--pharmacology
HIV Envelope Protein gp120--chemistry
HIV-1
Indoles--pharmacology
Kynurenic Acid--analogs & derivatives
Male
Maleimides--pharmacology
Neurons--metabolism
Nitroarginine--pharmacology
Peptide Fragments--metabolism
Pipecolic Acids--pharmacology
Piperazines--pharmacology
Piperidines--pharmacology
Potassium--pharmacology
Protein Structure, Tertiary
Rats
Rats, Sprague-Dawley
Receptors, N-Methyl-D-Aspartate--metabolism
Somatostatin--metabolism
Synaptic Transmission--drug effects
Synaptosomes--metabolism
Zinc--pharmacology