Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein.

Sadeghi, M M

Simvastatin modulates cytokine-mediated endothelial cell adhesion molecule induction: involvement of an inhibitory G protein. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Sep 2000 - 2712-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0022-1767

10.4049/jimmunol.165.5.2712 doi


Adjuvants, Immunologic--pharmacology
Biological Transport--drug effects
Cell Adhesion Molecules--biosynthesis
Cells, Cultured
Cholesterol--biosynthesis
Cytokines--physiology
Drug Synergism
E-Selectin--biosynthesis
Endothelium, Vascular--drug effects
GTP-Binding Protein alpha Subunits, Gi-Go--physiology
Gene Expression Regulation--drug effects
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors--pharmacology
Intercellular Adhesion Molecule-1--biosynthesis
Interleukin-1--antagonists & inhibitors
NF-kappa B--metabolism
RNA, Messenger--metabolism
Signal Transduction--immunology
Simvastatin--pharmacology
Sodium Fluoride--pharmacology
Umbilical Veins
Vascular Cell Adhesion Molecule-1--biosynthesis