In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia.

Barrow, J C

In vitro and in vivo evaluation of dihydropyrimidinone C-5 amides as potent and selective alpha(1A) receptor antagonists for the treatment of benign prostatic hyperplasia. [electronic resource] - Journal of medicinal chemistry Jul 2000 - 2703-18 p. digital

Publication Type: Journal Article

0022-2623

10.1021/jm990612y doi


Adrenergic alpha-Antagonists--chemical synthesis
Animals
Biological Availability
Caco-2 Cells
Crystallography, X-Ray
Dogs
Humans
Male
Prostatic Hyperplasia--drug therapy
Pyrimidinones--chemical synthesis
Radioligand Assay
Rats
Rats, Sprague-Dawley
Receptors, Adrenergic, alpha-1--drug effects
Structure-Activity Relationship