Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine.

Xu-Welliver, M

Point mutations at multiple sites including highly conserved amino acids maintain activity, but render O6-alkylguanine-DNA alkyltransferase insensitive to O6-benzylguanine. [electronic resource] - The Biochemical journal Apr 2000 - 519-26 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0264-6021

10.1042/0264-6021:3470519 doi


Amino Acid Sequence
Amino Acid Substitution--genetics
Antineoplastic Agents--pharmacology
Binding Sites
Conserved Sequence--genetics
DNA Repair--drug effects
Drug Resistance--genetics
Escherichia coli
Gene Library
Guanine--analogs & derivatives
Humans
Methylnitronitrosoguanidine--pharmacology
Molecular Sequence Data
O(6)-Methylguanine-DNA Methyltransferase--chemistry
Point Mutation--genetics
Sequence Alignment