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Perkins, C

Arsenic induces apoptosis of multidrug-resistant human myeloid leukemia cells that express Bcr-Abl or overexpress MDR, MRP, Bcl-2, or Bcl-x(L). [electronic resource] - Blood Feb 2000 - 1014-22 p. digital

Publication Type: Journal Article

ISSN: 0006-4971

Subjects--Topical Terms:
ATP Binding Cassette Transporter, Subfamily B, Member 1--biosynthesis
ATP-Binding Cassette Transporters--biosynthesis
Acetylation--drug effects
Antineoplastic Agents--pharmacology
Apoptosis--drug effects
Apoptotic Protease-Activating Factor 1
Arsenic Trioxide
Arsenicals--pharmacology
Caspases--metabolism
Cytochrome c Group--metabolism
Cytosol--metabolism
Drug Resistance, Multiple
Drug Resistance, Neoplasm
Fas Ligand Protein
Fusion Proteins, bcr-abl--biosynthesis
Gene Expression Regulation, Leukemic
Genes, bcl-2
HL-60 Cells--drug effects
Histones--metabolism
Humans
Immunophenotyping
K562 Cells--drug effects
Leukemia, Myelogenous, Chronic, BCR-ABL Positive--genetics
Macrophage-1 Antigen--biosynthesis
Membrane Glycoproteins--biosynthesis
Mitochondria--metabolism
Multidrug Resistance-Associated Proteins
Neoplasm Proteins--biosynthesis
Oxides--pharmacology
Protein Biosynthesis
Protein Processing, Post-Translational--drug effects
Proteins--genetics
Proto-Oncogene Proteins--biosynthesis
Proto-Oncogene Proteins c-bcl-2--biosynthesis
bcl-2-Associated X Protein
bcl-X Protein
fas Receptor--biosynthesis