Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells.

Barnes, M J

Development of a whole cell assay to measure methotrexate-induced inhibition of thymidylate synthase and de novo purine synthesis in leukaemia cells. [electronic resource] - Biochemical pharmacology Feb 2000 - 321-8 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0006-2952

10.1016/s0006-2952(99)00320-2 doi


Adenine--biosynthesis
Antimetabolites, Antineoplastic--pharmacology
Child
Guanine--biosynthesis
Humans
Inosine--metabolism
Leukemia--metabolism
Methotrexate--pharmacology
Precursor Cell Lymphoblastic Leukemia-Lymphoma--metabolism
Purines--biosynthesis
Thymidine--metabolism
Thymidylate Synthase--antagonists & inhibitors
Tumor Cells, Cultured