Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors.

Pascal, Y

Synthesis and structure-activity relationships of 4-oxo-1-phenyl-3,4,6,7-tetrahydro-[1,4]diazepino[6,7,1-hi]indoles: novel PDE4 inhibitors. [electronic resource] - Bioorganic & medicinal chemistry letters Jan 2000 - 35-8 p. digital

Publication Type: Journal Article

0960-894X

10.1016/s0960-894x(99)00573-9 doi


3',5'-Cyclic-AMP Phosphodiesterases--antagonists & inhibitors
Animals
Benzodiazepines--chemical synthesis
Binding Sites
Cyclic Nucleotide Phosphodiesterases, Type 4
Dogs
Guinea Pigs
Humans
Indoles--chemical synthesis
Inhibitory Concentration 50
Phosphodiesterase Inhibitors--chemical synthesis
Rats
Rats, Inbred BN
Rats, Wistar
Rolipram--metabolism
Stereoisomerism
Structure-Activity Relationship
Substrate Specificity
U937 Cells