Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na(+) channel to the cell surface.

Snyder, P M

Liddle's syndrome mutations disrupt cAMP-mediated translocation of the epithelial Na(+) channel to the cell surface. [electronic resource] - The Journal of clinical investigation Jan 2000 - 45-53 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0021-9738

10.1172/JCI7869 doi


1-Methyl-3-isobutylxanthine--pharmacology
Animals
Biological Transport
Cells, Cultured
Cyclic AMP--physiology
Cystic Fibrosis Transmembrane Conductance Regulator--physiology
Epithelium--metabolism
Hypertension--genetics
Mesylates--pharmacology
Mutation
Rats
Rats, Inbred F344
Sodium--metabolism
Sodium Channels--genetics