Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription.

O'Keeffe, B

Requirement for a kinase-specific chaperone pathway in the production of a Cdk9/cyclin T1 heterodimer responsible for P-TEFb-mediated tat stimulation of HIV-1 transcription. [electronic resource] - The Journal of biological chemistry Jan 2000 - 279-87 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.

0021-9258

10.1074/jbc.275.1.279 doi


Benzoquinones
Cell Cycle Proteins--metabolism
Chaperonins
Cyclin T
Cyclin-Dependent Kinase 9
Cyclin-Dependent Kinases--metabolism
Cyclins--metabolism
DNA Polymerase II--metabolism
Dimerization
Drosophila Proteins
Enzyme Activation
Gene Products, tat--metabolism
HIV-1--genetics
HSP70 Heat-Shock Proteins--metabolism
HSP90 Heat-Shock Proteins--metabolism
Humans
Lactams, Macrocyclic
Molecular Chaperones--metabolism
Positive Transcriptional Elongation Factor B
Protein Binding--drug effects
Protein Serine-Threonine Kinases--metabolism
Quinones--pharmacology
Species Specificity
Transcription, Genetic
tat Gene Products, Human Immunodeficiency Virus