Phosphoinositide 3-hydroxide kinase blockade enhances apoptosis in the Ewing's sarcoma family of tumors.

Toretsky, J A

Phosphoinositide 3-hydroxide kinase blockade enhances apoptosis in the Ewing's sarcoma family of tumors. [electronic resource] - Cancer research Nov 1999 - 5745-50 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0008-5472


Androstadienes--pharmacology
Antineoplastic Agents--antagonists & inhibitors
Apoptosis--genetics
Caspase 3
Caspases--metabolism
Cell Transformation, Neoplastic--chemically induced
DNA Fragmentation
Doxorubicin--antagonists & inhibitors
Enzyme Activation--drug effects
Enzyme Inhibitors--pharmacology
Humans
In Situ Nick-End Labeling
Insulin-Like Growth Factor I--pharmacology
Neoplasm Proteins--antagonists & inhibitors
Phosphatidylinositol 3-Kinases--metabolism
Phosphoinositide-3 Kinase Inhibitors
Protein Serine-Threonine Kinases--physiology
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-akt
Receptor, IGF Type 1
Sarcoma, Ewing--enzymology
Tumor Cells, Cultured--drug effects
Wortmannin