Nepalolide A inhibits the expression of inducible nitric oxide synthase by modulating the degradation of IkappaB-alpha and IkappaB-beta in C6 glioma cells and rat primary astrocytes.

Wang, C N

Nepalolide A inhibits the expression of inducible nitric oxide synthase by modulating the degradation of IkappaB-alpha and IkappaB-beta in C6 glioma cells and rat primary astrocytes. [electronic resource] - British journal of pharmacology Sep 1999 - 345-56 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0007-1188

10.1038/sj.bjp.0702785 doi


Animals
Anthracenes--pharmacology
Astrocytes--drug effects
Biotransformation--drug effects
Blotting, Western
Brain Neoplasms--metabolism
Cell Survival--drug effects
Cells, Cultured
DNA-Binding Proteins--metabolism
Depression, Chemical
Electrophoresis
Enzyme Inhibitors--pharmacology
Glioma--metabolism
I-kappa B Proteins
Interferon-gamma--antagonists & inhibitors
NF-KappaB Inhibitor alpha
NF-kappa B--antagonists & inhibitors
Nitric Oxide Synthase--antagonists & inhibitors
Nitric Oxide Synthase Type II
Nitrites--metabolism
Oligonucleotides--metabolism
Precipitin Tests
RNA, Messenger--biosynthesis
Rats
Rats, Sprague-Dawley
Recombinant Proteins