The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity.

Kelly, S L

The G464S amino acid substitution in Candida albicans sterol 14alpha-demethylase causes fluconazole resistance in the clinic through reduced affinity. [electronic resource] - Biochemical and biophysical research communications Aug 1999 - 174-9 p. digital

Publication Type: Journal Article

0006-291X

10.1006/bbrc.1999.1136 doi


Amino Acid Sequence
Amino Acid Substitution
Antifungal Agents--metabolism
Candida albicans--drug effects
Carbon Monoxide--metabolism
Catalysis
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--chemistry
Drug Resistance, Microbial
Ergosterol--biosynthesis
Fluconazole--metabolism
Heme--chemistry
Inhibitory Concentration 50
Kinetics
Mutagenesis, Site-Directed
Oxidation-Reduction
Oxidoreductases--antagonists & inhibitors
Protein Binding
Saccharomyces cerevisiae--genetics
Spectrum Analysis
Sterol 14-Demethylase