Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis.
Carmeliet, P
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. [electronic resource] - Cell Jul 1999 - 147-57 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0092-8674
10.1016/s0092-8674(00)81010-7 doi
Animals
Antigens, CD
Apoptosis--physiology
Cadherins--genetics
Cell Survival--physiology
Cytoskeletal Proteins--physiology
Cytosol--chemistry
DNA Primers
Endothelial Growth Factors--physiology
Endothelium, Vascular--chemistry
Fetus--cytology
Gene Expression Regulation, Developmental
Hematopoiesis--physiology
In Situ Nick-End Labeling
Intercellular Junctions--physiology
Lymphokines--physiology
Mice
Mice, Transgenic
Microscopy, Electron
Mutagenesis, Site-Directed
Neovascularization, Physiologic--physiology
Phosphatidylinositol 3-Kinases--metabolism
Receptor Protein-Tyrosine Kinases--physiology
Receptors, Growth Factor--physiology
Receptors, Vascular Endothelial Growth Factor
Signal Transduction--physiology
Trans-Activators
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
beta Catenin
Targeted deficiency or cytosolic truncation of the VE-cadherin gene in mice impairs VEGF-mediated endothelial survival and angiogenesis. [electronic resource] - Cell Jul 1999 - 147-57 p. digital
Publication Type: Journal Article; Research Support, Non-U.S. Gov't
0092-8674
10.1016/s0092-8674(00)81010-7 doi
Animals
Antigens, CD
Apoptosis--physiology
Cadherins--genetics
Cell Survival--physiology
Cytoskeletal Proteins--physiology
Cytosol--chemistry
DNA Primers
Endothelial Growth Factors--physiology
Endothelium, Vascular--chemistry
Fetus--cytology
Gene Expression Regulation, Developmental
Hematopoiesis--physiology
In Situ Nick-End Labeling
Intercellular Junctions--physiology
Lymphokines--physiology
Mice
Mice, Transgenic
Microscopy, Electron
Mutagenesis, Site-Directed
Neovascularization, Physiologic--physiology
Phosphatidylinositol 3-Kinases--metabolism
Receptor Protein-Tyrosine Kinases--physiology
Receptors, Growth Factor--physiology
Receptors, Vascular Endothelial Growth Factor
Signal Transduction--physiology
Trans-Activators
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
beta Catenin