Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni.

Hoffmann, K F

Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. [electronic resource] - Journal of immunology (Baltimore, Md. : 1950) Jul 1999 - 927-38 p. digital

Publication Type: Journal Article

0022-1767


Animals
Antibodies, Helminth--biosynthesis
Antigens, Helminth--immunology
Bronchi--blood supply
Cytokines--biosynthesis
Female
Immunity, Cellular--genetics
Immunization, Secondary
Interferon-gamma--biosynthesis
Interleukin-10--deficiency
Interleukin-4--biosynthesis
Larva--immunology
Lung--blood supply
Lymphocyte Subsets--immunology
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Nitric Oxide--biosynthesis
Schistosoma mansoni--growth & development
Schistosomiasis mansoni--genetics
Th1 Cells--immunology
Th2 Cells--immunology
Vaccines, Attenuated--administration & dosage