Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease.

Chan, V J

Expression and alteration of the S2 subsite of the Leishmania major cathepsin B-like cysteine protease. [electronic resource] - The Biochemical journal May 1999 - 113-7 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0264-6021


Amino Acid Sequence
Animals
Binding Sites
Cathepsin B--antagonists & inhibitors
Coumarins--metabolism
Dipeptides--pharmacology
Glutamic Acid--genetics
Glycine--genetics
Humans
Hydrogen-Ion Concentration
Kinetics
Leishmania major--enzymology
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Pichia--genetics
Rats
Recombinant Proteins--biosynthesis
Sequence Homology, Amino Acid
Structure-Activity Relationship
Substrate Specificity
Sulfones--pharmacology