E2F-1 has properties of a radiosensitizer and its regulation by cyclin A kinase is required for cell survival of fibrosarcoma cells lacking p53.

Pruschy, M

E2F-1 has properties of a radiosensitizer and its regulation by cyclin A kinase is required for cell survival of fibrosarcoma cells lacking p53. [electronic resource] - Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research Mar 1999 - 141-6 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

1044-9523


Animals
Carrier Proteins
Cell Cycle Proteins
Cell Line, Transformed
Cell Survival
DNA-Binding Proteins
E2F Transcription Factors
E2F1 Transcription Factor
Fibrosarcoma--genetics
Gene Expression
Genes, p53
Mice
Mice, Nude
Protein Kinases--metabolism
Protein Synthesis Inhibitors--metabolism
Puromycin--metabolism
Radiation Tolerance--physiology
Retinoblastoma-Binding Protein 1
Time Factors
Transcription Factor DP1
Transcription Factors--metabolism
Tumor Suppressor Protein p53--deficiency