Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma.

Ajizian, S J

Specific inhibitors of p38 and extracellular signal-regulated kinase mitogen-activated protein kinase pathways block inducible nitric oxide synthase and tumor necrosis factor accumulation in murine macrophages stimulated with lipopolysaccharide and interferon-gamma. [electronic resource] - The Journal of infectious diseases Apr 1999 - 939-44 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't

0022-1899

10.1086/314659 doi


Calcium-Calmodulin-Dependent Protein Kinases--antagonists & inhibitors
Cells, Cultured
Dose-Response Relationship, Drug
Flavonoids--pharmacology
Humans
Imidazoles--pharmacology
Interferon-gamma--pharmacology
Lipopolysaccharides--pharmacology
Macrophages
Mitogen-Activated Protein Kinases
Nitric Oxide--biosynthesis
Nitric Oxide Synthase--antagonists & inhibitors
Nitric Oxide Synthase Type II
Pyridines--pharmacology
Tumor Necrosis Factor-alpha--antagonists & inhibitors
p38 Mitogen-Activated Protein Kinases