Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation. [electronic resource]
Producer: 19981116Description: 868-74 p. digitalISSN:- 0090-9556
- Animals
- Aryl Hydrocarbon Hydroxylases
- Cytochrome P-450 CYP1A2 -- metabolism
- Cytochrome P-450 CYP2C19
- Cytochrome P-450 Enzyme Inhibitors
- Cytochrome P-450 Enzyme System -- metabolism
- Dealkylation
- Enzyme Inhibitors -- pharmacology
- Estradiol Congeners -- metabolism
- Humans
- In Vitro Techniques
- Insecticides -- pharmacokinetics
- Isoenzymes -- metabolism
- Kinetics
- Male
- Methoxychlor -- pharmacokinetics
- Microsomes, Liver -- metabolism
- Mixed Function Oxygenases -- metabolism
- Rats
- Rats, Sprague-Dawley
- Recombinant Proteins -- metabolism
- Regression Analysis
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Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.
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