Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation.

Stresser, D M

Human cytochrome P450-catalyzed conversion of the proestrogenic pesticide methoxychlor into an estrogen. Role of CYP2C19 and CYP1A2 in O-demethylation. [electronic resource] - Drug metabolism and disposition: the biological fate of chemicals Sep 1998 - 868-74 p. digital

Publication Type: Journal Article; Research Support, U.S. Gov't, P.H.S.

0090-9556


Animals
Aryl Hydrocarbon Hydroxylases
Cytochrome P-450 CYP1A2--metabolism
Cytochrome P-450 CYP2C19
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System--metabolism
Dealkylation
Enzyme Inhibitors--pharmacology
Estradiol Congeners--metabolism
Humans
In Vitro Techniques
Insecticides--pharmacokinetics
Isoenzymes--metabolism
Kinetics
Male
Methoxychlor--pharmacokinetics
Microsomes, Liver--metabolism
Mixed Function Oxygenases--metabolism
Rats
Rats, Sprague-Dawley
Recombinant Proteins--metabolism
Regression Analysis