Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. [electronic resource]
Producer: 19980512Description: 2634-42 p. digitalISSN:- 0006-4971
- Chromosomes, Human, Pair 15
- Chromosomes, Human, Pair 17
- DNA-Binding Proteins -- genetics
- Drug Resistance, Neoplasm -- genetics
- Gene Expression Regulation, Neoplastic -- drug effects
- Humans
- Kruppel-Like Transcription Factors
- Leukemia, Promyelocytic, Acute -- drug therapy
- Neoplasm Proteins -- genetics
- Nuclear Proteins -- genetics
- Nuclear Receptor Co-Repressor 1
- Oncogene Proteins, Fusion -- genetics
- Promyelocytic Leukemia Zinc Finger Protein
- Protein Binding
- Repressor Proteins -- genetics
- Transcription Factors -- genetics
- Translocation, Genetic
- Tretinoin -- pharmacology
- Tumor Cells, Cultured
- Zinc Fingers
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Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.
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