Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia.

Guidez, F

Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. [electronic resource] - Blood Apr 1998 - 2634-42 p. digital

Publication Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.

0006-4971


Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 17
DNA-Binding Proteins--genetics
Drug Resistance, Neoplasm--genetics
Gene Expression Regulation, Neoplastic--drug effects
Humans
Kruppel-Like Transcription Factors
Leukemia, Promyelocytic, Acute--drug therapy
Neoplasm Proteins--genetics
Nuclear Proteins--genetics
Nuclear Receptor Co-Repressor 1
Oncogene Proteins, Fusion--genetics
Promyelocytic Leukemia Zinc Finger Protein
Protein Binding
Repressor Proteins--genetics
Transcription Factors--genetics
Translocation, Genetic
Tretinoin--pharmacology
Tumor Cells, Cultured
Zinc Fingers