Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed by symmetrical and unsymmetrical polyamines. [electronic resource]
Producer: 19941103Description: 3363-72 p. digitalISSN:- 0022-2623
- Animals
- Atrial Function
- Benzodiazepines -- chemical synthesis
- Cells, Cultured
- Cerebral Cortex -- metabolism
- Drug Design
- Female
- Guinea Pigs
- Heart Atria -- drug effects
- Ileum -- drug effects
- Male
- Molecular Structure
- Muscarinic Antagonists
- Muscle Contraction -- drug effects
- Myocardial Contraction -- drug effects
- Myocardium -- metabolism
- Polyamines -- chemical synthesis
- Rats
- Receptors, Muscarinic -- metabolism
- Structure-Activity Relationship
- Submandibular Gland -- metabolism
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Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't
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