Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed by symmetrical and unsymmetrical polyamines.

Minarini, A

Design, synthesis, and biological activity of methoctramine-related tetraamines bearing an 11-acetyl-5,11-dihydro-6H-pyrido[2,3-b][1,4] benzodiazepin-6-one moiety: structural requirements for optimum occupancy of muscarinic receptor subtypes as revealed by symmetrical and unsymmetrical polyamines. [electronic resource] - Journal of medicinal chemistry Sep 1994 - 3363-72 p. digital

Publication Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't

0022-2623

10.1021/jm00046a021 doi


Animals
Atrial Function
Benzodiazepines--chemical synthesis
Cells, Cultured
Cerebral Cortex--metabolism
Drug Design
Female
Guinea Pigs
Heart Atria--drug effects
Ileum--drug effects
Male
Molecular Structure
Muscarinic Antagonists
Muscle Contraction--drug effects
Myocardial Contraction--drug effects
Myocardium--metabolism
Polyamines--chemical synthesis
Rats
Receptors, Muscarinic--metabolism
Structure-Activity Relationship
Submandibular Gland--metabolism