Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology. [electronic resource]
Producer: 20210224Description: 103616 p. digitalISSN:- 1090-2120
- Cell Line, Tumor
- Drug Design
- Drug Screening Assays, Antitumor
- Humans
- Matrix Metalloproteinase 10 -- metabolism
- Matrix Metalloproteinase 13 -- metabolism
- Matrix Metalloproteinase Inhibitors -- chemistry
- Molecular Docking Simulation
- Neoplasms -- drug therapy
- Polypharmacology
- Pyridines -- chemistry
- Structure-Activity Relationship
- Triazoles -- chemistry
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Publication Type: Journal Article
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