Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology.

El Ashry, El Sayed Helmy

Structure-based design and optimization of pyrimidine- and 1,2,4-triazolo[4,3-a]pyrimidine-based matrix metalloproteinase-10/13 inhibitors via Dimroth rearrangement towards targeted polypharmacology. [electronic resource] - Bioorganic chemistry 03 2020 - 103616 p. digital

Publication Type: Journal Article

1090-2120

10.1016/j.bioorg.2020.103616 doi


Cell Line, Tumor
Drug Design
Drug Screening Assays, Antitumor
Humans
Matrix Metalloproteinase 10--metabolism
Matrix Metalloproteinase 13--metabolism
Matrix Metalloproteinase Inhibitors--chemistry
Molecular Docking Simulation
Neoplasms--drug therapy
Polypharmacology
Pyridines--chemistry
Structure-Activity Relationship
Triazoles--chemistry