Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models. [electronic resource]
Producer: 20200514Description: eaaw9162 p. digitalISSN:- 2375-2548
- Animals
- Antineoplastic Agents -- chemistry
- Colorectal Neoplasms -- drug therapy
- Delayed-Action Preparations -- chemistry
- Drug Resistance, Neoplasm -- drug effects
- HCT116 Cells
- HT29 Cells
- Humans
- Mice
- X-Linked Inhibitor of Apoptosis Protein -- antagonists & inhibitors
- Xenograft Model Antitumor Assays
- bcl-X Protein -- antagonists & inhibitors
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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