Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.

Manzari, Mandana T

Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models. [electronic resource] - Science advances 09 2019 - eaaw9162 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

2375-2548

10.1126/sciadv.aaw9162 doi


Animals
Antineoplastic Agents--chemistry
Colorectal Neoplasms--drug therapy
Delayed-Action Preparations--chemistry
Drug Resistance, Neoplasm--drug effects
HCT116 Cells
HT29 Cells
Humans
Mice
X-Linked Inhibitor of Apoptosis Protein--antagonists & inhibitors
Xenograft Model Antitumor Assays
bcl-X Protein--antagonists & inhibitors