Intrinsic Resistance to MEK Inhibition through BET Protein-Mediated Kinome Reprogramming in NF1-Deficient Ovarian Cancer. [electronic resource]
Producer: 20200416Description: 1721-1734 p. digitalISSN:- 1557-3125
- Cell Cycle Proteins -- antagonists & inhibitors
- Drug Resistance, Neoplasm -- drug effects
- Drug Therapy, Combination
- Female
- Humans
- MAP Kinase Kinase 1 -- antagonists & inhibitors
- MAP Kinase Signaling System
- Neurofibromin 1 -- deficiency
- Ovarian Neoplasms -- drug therapy
- Protein Kinase Inhibitors -- pharmacology
- Receptor Protein-Tyrosine Kinases -- antagonists & inhibitors
- Signal Transduction
- Transcription Factors -- antagonists & inhibitors
- Tumor Cells, Cultured
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Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
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