Intrinsic Resistance to MEK Inhibition through BET Protein-Mediated Kinome Reprogramming in NF1-Deficient Ovarian Cancer.

Kurimchak, Alison M

Intrinsic Resistance to MEK Inhibition through BET Protein-Mediated Kinome Reprogramming in NF1-Deficient Ovarian Cancer. [electronic resource] - Molecular cancer research : MCR 08 2019 - 1721-1734 p. digital

Publication Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't

1557-3125

10.1158/1541-7786.MCR-18-1332 doi


Cell Cycle Proteins--antagonists & inhibitors
Drug Resistance, Neoplasm--drug effects
Drug Therapy, Combination
Female
Humans
MAP Kinase Kinase 1--antagonists & inhibitors
MAP Kinase Signaling System
Neurofibromin 1--deficiency
Ovarian Neoplasms--drug therapy
Protein Kinase Inhibitors--pharmacology
Receptor Protein-Tyrosine Kinases--antagonists & inhibitors
Signal Transduction
Transcription Factors--antagonists & inhibitors
Tumor Cells, Cultured