Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs. [electronic resource]
Producer: 20171009Description: 1542-1554 p. digitalISSN:- 1860-7187
- Animals
- Binding Sites
- Carboxylic Acids -- chemistry
- Cell Line, Tumor
- Cell Proliferation -- drug effects
- Drug Design
- Enzyme Inhibitors -- chemistry
- Humans
- Hydrogen Bonding
- Inhibitory Concentration 50
- Mice
- Microsomes -- metabolism
- Molecular Dynamics Simulation
- Phosphatidylinositol 3-Kinases -- metabolism
- Phosphoinositide-3 Kinase Inhibitors
- Prodrugs -- chemistry
- Protein Binding
- Protein Isoforms -- antagonists & inhibitors
- Quinolones -- chemistry
- Structure-Activity Relationship
No physical items for this record
Publication Type: Journal Article
There are no comments on this title.
Log in to your account to post a comment.